Surface Modifications of Titanium Plates to Enhance Osteogenesis: Advances, Challenges, and Clinical Insights
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Randy Bachelard Nziengui Raby
Institute of Biomedical Engineering, Central South University, Yuelu District, Changsha 410011, Hunan, People’s Republic of China
Guy Armel Bounda
Section Académique, Association des Etudiants et Stagiaires Gabonais de Chine, Beijing 100600, People’s Republic of China
Kelvin Stefel Lebila MoutsiDepartment of Radiology, The Second Xiangya Hospital, Central South University, 139# Middle Renmin Road, Changsha 410011, Hunan, People’s Republic of China
Idriss François Ntsame AllogoSchool of Public Health, Central South University, Yuelu District, Changsha 410011, Hunan, People’s Republic of China
Justia Varaine Mengue ObameSection Académique, Association des Etudiants et Stagiaires Gabonais de Chine, Beijing 100600, People’s Republic of China
Monique Lauriane Adou OvoloAnhui Polytechnic University, Beijing Middle Road, Wuhu 241000, Anhui, People’s Republic of China
Kwensy Djoyce OndoDepartment of Orthopaedics and Traumatology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Pudong District Shangnan Road 1000 Longshang Gangercun 45#, Shanghai, People’s Republic of China
Geraldine Esther AwakossaCancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China
Kiny-Binyumbe DoukagaDepartment of Gynecology and Obstetrics, Shandong First Medical University, 619# Great Wall Road Beijipo Street, Daiyue District, Tai'an, Shandong, People’s Republic of China
Rosanna Tryphene Massounga MayomboInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277# Jiefang Avenue, Wuhan 430022, Hubei, People’s Republic of China
Dally Mengue Bea MedzangDepartment of Internal Medicine, The Third Xiangya Hospital, Central South University, 139# Middle Renmin Road, Changsha 410011, Hunan, People’s Republic of China
Marie Mical Tsamba MpiraDepartment of Internal Medicine, The Third Xiangya Hospital, Central South University, 139# Middle Renmin Road, Changsha 410011, Hunan, People’s Republic of China
Maywann BengonoZhejiang University of Traditional Chinese Medicine, 548# Binwen Road, Binjiang District, Hangzhou, Zhejiang, People’s Republic of China
Ulrich Freddy Nziengui MbadingaDepartment of Food Science and Engineering, Changsha University of Science and Technology, 960, 2" Section, Wanjiali South RD, Changsha 410004, Hunan, People’s Republic of China
Maëlle Noémie Mengue ObameDepartment of Pharmacy, Linyi University, Middle of Shuangling Road, Linyi City 410004, Shandong, People’s Republic of China
Noreen Teingue DodoDepartment of Gynecology and Obstetrics, Dalian Medical University, 9 West Section, Lvshun South Road, Dalian 116041, Liaoning, People’s Republic of China
Zhi HuangInstitute of Biomedical Engineering, Central South University, Yuelu District, Changsha 410011, Hunan, People’s Republic of China
| Received 21 Apr, 2025 |
Accepted 20 Jun, 2025 |
Published 21 Jun, 2025 |
Titanium and its alloys are indispensable in bone regeneration and implantology due to their superior biocompatibility and mechanical strength. This review synthesizes recent advances in titanium plate surface modifications for osteogenesis, focusing on innovative approaches in surface engineering, such as the integration of nanomaterials, bioactive coatings, and laser treatments, to enhance osseointegration, antibacterial properties, and implant durability. A systematic literature search (2010-2024) was conducted across PubMed, Web of Science, Scopus, and ScienceDirect to comprehensively capture high-quality studies in this field. A critical assessment places these modifications within the context of improved clinical outcomes in orthopedic and reconstructive surgeries, addressing challenges of long-term stability, cost-effectiveness, and regulatory compliance. Overall, this comprehensive analysis provides valuable insights into current practices and outlines future research directions essential for optimizing implant performance, aligning with the scope of challenges by presenting innovative solutions in the rapidly evolving field of biomaterials.
How to Cite this paper?
APA-7 Style
Raby,
R.B., Bounda,
G.A., Moutsi,
K.S., Allogo,
I.F., Obame,
J.V., Ovolo,
M.L., Ondo,
K.D., Awakossa,
G.E., Doukaga,
K., Mayombo,
R.T., Medzang,
D.M., Mpira,
M.M., Bengono,
M., Mbadinga,
U.F., Obame,
M.N., Dodo,
N.T., Huang,
Z. (2025). Surface Modifications of Titanium Plates to Enhance Osteogenesis: Advances, Challenges, and Clinical Insights. Trends in Medical Research, 20(1), 21-43. https://doi.org/10.3923/tmr.2025.21.43
ACS Style
Raby,
R.B.; Bounda,
G.A.; Moutsi,
K.S.; Allogo,
I.F.; Obame,
J.V.; Ovolo,
M.L.; Ondo,
K.D.; Awakossa,
G.E.; Doukaga,
K.; Mayombo,
R.T.; Medzang,
D.M.; Mpira,
M.M.; Bengono,
M.; Mbadinga,
U.F.; Obame,
M.N.; Dodo,
N.T.; Huang,
Z. Surface Modifications of Titanium Plates to Enhance Osteogenesis: Advances, Challenges, and Clinical Insights. Trends Med. Res 2025, 20, 21-43. https://doi.org/10.3923/tmr.2025.21.43
AMA Style
Raby
RB, Bounda
GA, Moutsi
KS, Allogo
IF, Obame
JV, Ovolo
ML, Ondo
KD, Awakossa
GE, Doukaga
K, Mayombo
RT, Medzang
DM, Mpira
MM, Bengono
M, Mbadinga
UF, Obame
MN, Dodo
NT, Huang
Z. Surface Modifications of Titanium Plates to Enhance Osteogenesis: Advances, Challenges, and Clinical Insights. Trends in Medical Research. 2025; 20(1): 21-43. https://doi.org/10.3923/tmr.2025.21.43
Chicago/Turabian Style
Raby, Randy, Bachelard Nziengui, Guy Armel Bounda, Kelvin Stefel Lebila Moutsi, Idriss François Ntsame Allogo, Justia Varaine Mengue Obame, Monique Lauriane Adou Ovolo, Kwensy Djoyce Ondo, Geraldine Esther Awakossa, Kiny-Binyumbe Doukaga, Rosanna Tryphene Massounga Mayombo, Dally Mengue Bea Medzang, Marie Mical Tsamba Mpira, Maywann Bengono, Ulrich Freddy Nziengui Mbadinga, Maëlle Noémie Mengue Obame, Noreen Teingue Dodo, and Zhi Huang.
2025. "Surface Modifications of Titanium Plates to Enhance Osteogenesis: Advances, Challenges, and Clinical Insights" Trends in Medical Research 20, no. 1: 21-43. https://doi.org/10.3923/tmr.2025.21.43
This work is licensed under a Creative Commons Attribution 4.0 International License.
