Impact of L-Arginine Supplementation on Thyroid Function in Male Wistar Rats Exposed to Dichlorvos

Background and Objective: Thyroid hormones cause the body to burn oxygen and produce heat. Thyroid hormone has a wide range of functions, therefore imbalances or excesses in hormone levels result in a variety of clinical symptoms. The study looks into how supplementing with L-arginine affects thyroid function in male Wistar rats that have been exposed to the common herbicide Dichlorvos (DDVP). The investigation of possible treatment strategies is warranted since thyroid dysfunction is a common health concern linked to environmental contaminants. Materials and Methods: The four groups of male Wistar rats were treated with control, dichlorvos, L-arginine and dichlorvos with L-arginine supplementation. Following treatment, thyroid function markers such as Triiodothyronine (T₃), Thyroxine (T₄) and Thyroid-Stimulating Hormone (TSH) levels were measured. Results: The dichlorvos-exposed group’s thyroid hormone levels were significantly different from the controls’, suggesting thyroid malfunction, according to the results. On the other hand, rats given L-arginine supplements in addition to dichlorvos exposure demonstrated significant preservation of thyroid function as shown by somewhat normalized hormone levels. Conclusion: This implies that L-arginine may have a protective effect against thyroid disturbance brought on by dichlorvos. Human health may be affected by learning how L-arginine supplementation reduces pesticide-induced thyroid dysfunction, especially in groups of people who are more susceptible to exposure to environmental toxins.