Research Article | Open Access
Volume 18 | Issue 1 | https://doi.org/10.3923/tmr.2023.152.160

Effect of Toll-Like Receptor 4 on Angiotensin II-Induced Cardiac Hypertrophy in Mice

    Junjun Shang

    Panzhihua Key Laboratory of Cardiomyopathy and Heart Failure, Affiliated Hospital of Panzhihua University, Panzhihua, Sichuan 617099, China

    Hailong Lin

    Affiliated Dalian Central Hospital, Dalian Medical University, Dalian, Liaoning 116000, China

    Yuqing Tian

    Affiliated Dalian Central Hospital, Dalian Medical University, Dalian, Liaoning 116000, China

    Lin Wu

    Panzhihua Key Laboratory of Cardiomyopathy and Heart Failure, Affiliated Hospital of Panzhihua University, Panzhihua, Sichuan 617099, China


Received
25 Sep, 2023		 Accepted
02 Nov, 2023		 Published
05 Nov, 2023

Background and Objective: The TLR4 plays an important role in the development of cardiovascular disease and is closely related to cardiac inflammation. This study aimed to investigate the role of TLR4 in Ang II-induced cardiac hypertrophy. Materials and Methods: The Ang II-induced cardiac hypertrophy model in C57BL/6 male mice was established and treated with TAK-242 for 4 weeks. The cross-sectional area of cardiomyocytes was evaluated by Hematoxylin and Eosin (H&E) staining. Cardiac fibrosis was measured with Masson staining. Vimentin expression was detected by immunohistochemistry. The mRNA expression of TLR4 was analyzed by RT-qPCR. Results: The Ang II-increased cardiac mass index, cardiac-tibial ratio, cross-sectional area of cardiomyocytes and cardiac fibrosis as well as vimentin and TLR4 expression. Administration of TAK-242 attenuated these effects induced by Ang II. Conclusion: The TLR4 plays a vital role in Ang II-induced cardiac hypertrophy. It provides a new target for the future treatment of cardiac hypertrophy.

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APA-7 Style
Shang, J., Lin, H., Tian, Y., Wu, L. (2023). Effect of Toll-Like Receptor 4 on Angiotensin II-Induced Cardiac Hypertrophy in Mice. Trends in Medical Research, 18(1), 152-160. https://doi.org/10.3923/tmr.2023.152.160

ACS Style
Shang, J.; Lin, H.; Tian, Y.; Wu, L. Effect of Toll-Like Receptor 4 on Angiotensin II-Induced Cardiac Hypertrophy in Mice. Trends Med. Res 2023, 18, 152-160. https://doi.org/10.3923/tmr.2023.152.160

AMA Style
Shang J, Lin H, Tian Y, Wu L. Effect of Toll-Like Receptor 4 on Angiotensin II-Induced Cardiac Hypertrophy in Mice. Trends in Medical Research. 2023; 18(1): 152-160. https://doi.org/10.3923/tmr.2023.152.160

Chicago/Turabian Style
Shang, Junjun, Hailong Lin, Yuqing Tian, and Lin Wu. 2023. "Effect of Toll-Like Receptor 4 on Angiotensin II-Induced Cardiac Hypertrophy in Mice" Trends in Medical Research 18, no. 1: 152-160. https://doi.org/10.3923/tmr.2023.152.160

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