Effect of Toll-Like Receptor 4 on Angiotensin II-Induced Cardiac Hypertrophy in Mice
Received 25 Sep, 2023 |
Accepted 02 Nov, 2023 |
Published 05 Nov, 2023 |
Background and Objective: The TLR4 plays an important role in the development of cardiovascular disease and is closely related to cardiac inflammation. This study aimed to investigate the role of TLR4 in Ang II-induced cardiac hypertrophy. Materials and Methods: The Ang II-induced cardiac hypertrophy model in C57BL/6 male mice was established and treated with TAK-242 for 4 weeks. The cross-sectional area of cardiomyocytes was evaluated by Hematoxylin and Eosin (H&E) staining. Cardiac fibrosis was measured with Masson staining. Vimentin expression was detected by immunohistochemistry. The mRNA expression of TLR4 was analyzed by RT-qPCR. Results: The Ang II-increased cardiac mass index, cardiac-tibial ratio, cross-sectional area of cardiomyocytes and cardiac fibrosis as well as vimentin and TLR4 expression. Administration of TAK-242 attenuated these effects induced by Ang II. Conclusion: The TLR4 plays a vital role in Ang II-induced cardiac hypertrophy. It provides a new target for the future treatment of cardiac hypertrophy.
How to Cite this paper?
APA-7 Style
Shang,
J., Lin,
H., Tian,
Y., Wu,
L. (2023). Effect of Toll-Like Receptor 4 on Angiotensin II-Induced Cardiac Hypertrophy in Mice. Trends in Medical Research, 18(1), 152-160. https://doi.org/10.3923/tmr.2023.152.160
ACS Style
Shang,
J.; Lin,
H.; Tian,
Y.; Wu,
L. Effect of Toll-Like Receptor 4 on Angiotensin II-Induced Cardiac Hypertrophy in Mice. Trends Med. Res 2023, 18, 152-160. https://doi.org/10.3923/tmr.2023.152.160
AMA Style
Shang
J, Lin
H, Tian
Y, Wu
L. Effect of Toll-Like Receptor 4 on Angiotensin II-Induced Cardiac Hypertrophy in Mice. Trends in Medical Research. 2023; 18(1): 152-160. https://doi.org/10.3923/tmr.2023.152.160
Chicago/Turabian Style
Shang, Junjun, Hailong Lin, Yuqing Tian, and Lin Wu.
2023. "Effect of Toll-Like Receptor 4 on Angiotensin II-Induced Cardiac Hypertrophy in Mice" Trends in Medical Research 18, no. 1: 152-160. https://doi.org/10.3923/tmr.2023.152.160
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